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Thrombotic microangiopathy due to snake evenomation: natural history and potential aetiologies.



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Snake venoms cause coagulopathy due to a variety of mechanisms.  Envenomation usually results in a venom induced consumptive coagulopathy (VICC), with depletion of fibrinogen, factor V and factor VIII.  VICC is an acute transient coagulopathy of which the major complication is bleeding.  

In a small proportion of these cases, features of a thrombotic microangiopathy (TMA) develop, marked by the presence of haemolytic anaemia with red cell fragmentation, thrombocytopenia and oliguric acute renal failure.  TMA associated due to snake envenoming is very poorly understood.  It is described in the literature in isolated case reports and small case series only.  A review of the literature and discussion of further investigations to elucidate the potential aetiology of TMA due to snake envenomation will be presented.

Dr Tina Noutsos is a part time haematologist at Royal Darwin Hospital and part time PhD student.  This presentation represents her confirmation of candidature