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Diabetes and Renal Disease in Indigenous Australians: insights from DRUID & eGFR Studies



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10 August 2009

Abstract: There is an overwhelming burden of type 2 diabetes, chronic kidney disease and end-stage renal failure in Indigenous Australians. The Darwin Region Urban Indigenous Diabetes (DRUID) Study was designed to address a knowledge gap about diabetes care and complications in the urban setting, where the majority of Indigenous Australians live; and involved approximately n=1000 participants aged from 15 years. Almost one-third (32%) of DRUID participants aged ≥35 years and over half (52%) of those aged ≥55 years had diabetes. Compared to the general Australian population (AusDiab study), DRUID participants had high rates of albuminuria but unexpectedly low rates of renal impairment (eGFR<60mls/min/1.73m2). With previous reports of differences in body build and body composition between Indigenous and non-Indigenous Australians, the unexpectedly low rates of renal impairment in the DRUID cohort suggest that the recommended formula for calculating estimates of GFR (eGFR) needs further assessment in Indigenous populations. The eGFR Study is a multi-centre study recruiting adult Indigenous Australian participants across 5 strata of health, diabetes status and renal function. The study aims to determine a validated and practical measure of GFR suitable for use in all Indigenous Australians.



Louise Maple-Brown

Menzies School of Health Research;

Division of Medicine, Royal Darwin Hospital